The main difference between a list and a tuple in Python is that a list is mutable, meaning it can be changed, while a tuple is immutable and cannot be changed. Lists are typically used for storing items that may need to be modified, while tuples are usually used to store items that won’t change.

PEP 8 is a style guide for writing Python code. It provides guidelines for coding style, including indentation, whitespace, naming conventions, and other best practices.

Some common Python mistakes include using incorrect indentation, forgetting to use parentheses for function calls, forgetting to use quotation marks for strings, forgetting to use the “self” keyword for instance methods, and forgetting to use the “yield” keyword in generators.